Multi-centric AI Model for Unruptured Intracranial Aneurysm Detection and Volumetric Segmentation in 3D TOF-MRI

The aim of this study was to develop an open-source nnU-Net-based AI model for combined detection and segmentation of unruptured intracranial aneurysms (UICA) in 3D TOF-MRI and compare models trained on datasets with aneurysm-like differential diagnoses. This retrospective study (2020-2023) included 385 anonymized 3D TOF-MRI images from 345 patients (mean age 59 years, 60% female) at multiple centers plus 113 subjects from the ADAM challenge. Images featured untreated or possible UICA and differential diagnoses. Four distinct training datasets were created, and the nnU-Net framework was used for model development. Performance was assessed on a separate test set using sensitivity and false positive (FP)/case rate for detection and DICE score and NSD (normalized surface distance, 0.5 mm threshold) for segmentation. Segmentation performance on the test set was also compared to a second human reader. The four models achieved overall sensitivity between 82 and 85% and an FP/case rate of 0.20 to 0.31, with no significant differences (p = 0.90 and p = 0.16) between them. The primary model showed 85% sensitivity and 0.23 FP/case rate, outperforming the ADAM-challenge winner (61%) and a nnU-Net trained on ADAM data (51%) in sensitivity (p < 0.05). Mean DICE (0.73) and NSD (0.84 for 0.5 mm threshold) for correctly detected UICA did not significantly differ from human reader performance. Our open-source, nnU-Net-based AI model (available at https://zenodo.org/records/13386859 ) demonstrates high sensitivity, low FP rates, and consistent segmentation accuracy for UICA detection and segmentation in 3D TOF-MRI, suggesting its potential to improve clinical diagnosis and monitoring of UICA.