The potential of food-derived peptides in alleviating depressed mood: Function, evaluation and mechanism

Food-derived peptides offer a promising approach to alleviating depressive symptoms due to their safety and natural origin, avoiding the adverse side effects of conventional pharmacological treatments. This review aims to explore their potential in mitigating depressive symptoms. Antidepressant peptides from both animal and plant sources have been reviewed, while the animal models and evaluation methods used to assess their efficacy have been summarized. The review highlights four major mechanisms underlying their effects, namely modulation of gut microbiota and production of neuroactive metabolites, alteration of molecules associated with nervous system, normalization of hypothalamic-pituitary-adrenal axis dysregulation to reduce cortisol production, and suppression of pro-inflammatory cytokines linked to neuroinflammation. It also highlights the role of gut-brain axis in mediating the mechanisms, which has been insufficiently elucidated. However, the efficacy of antidepressant peptides for clinical use has not been established. The present review provides a reference for developing dietary interventions with food-derived peptides to supplement current therapeutic approaches.