Tigecycline Induced Sweet Syndrome in a Patient on Maintenance Hemodialysis

Sweet syndrome or acute febrile neutrophilic dermatosis is a very uncommon condition, especially in patients on chronic hemodialysis. Sweet syndrome is characterized by painful erythematous plaques, papules, and nodules of abrupt onset, associated with fever and malaise. We describe a 44-year-old woman on chronic hemodialysis due to diabetic nephropathy who developed Sweet syndrome after intravenous administration of tigecycline due to an enterococcus infection. There is a paucity of data regarding Sweet syndrome in hemodialysis patients; nevertheless, this syndrome merits more attention in nephrological clinical practice. We suggest that Sweet syndrome should be considered if the abrupt appearance of erythematous plaques and nodules with fever is presented in a hemodialysis patient. Nephrologists should be aware of this uncommon condition in order to timely recognize this syndrome. Interestingly, tigecycline is another drug implicated in the development of drug-induced Sweet syndrome.