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Endobronchial valve treatment improves diaphragm function in severe emphysema patients
Else A M D Ter Haar1,2, Dirk-Jan Slebos1,2, Jens T Bakker1,2
1University of Groningen, University Medical Centre Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands.
ERJ Open Research
|May 13, 2025
Summary
Endobronchial valve (EBV) treatment improves diaphragm function in severe emphysema patients by reducing lung hyperinflation. This intervention helps restore diaphragm mechanics and strength, offering a potential therapeutic benefit.
Area of Science:
- Pulmonology
- Respiratory Medicine
- Medical Devices
Background:
- Diaphragm dysfunction is prevalent in severe emphysema, stemming from lung hyperinflation that compromises diaphragm mechanics.
- Endobronchial valve (EBV) treatment is a bronchoscopic intervention aimed at reducing hyperinflation.
Purpose of the Study:
- To investigate the impact of EBV treatment on diaphragm function in patients with severe emphysema.
- To assess changes in diaphragm motion, activity, and strength following EBV therapy.
Main Methods:
- A prospective cohort study involving 25 severe emphysema patients.
- Diaphragm function assessed using ultrasound for motion and thickening, surface electromyography (sEMG) for activity, and maximal inspiratory pressure for strength.
- Measurements were taken at baseline and 6 weeks post-EBV treatment.
Main Results:
- Significant reduction in residual volume post-EBV treatment.
- Significant increase in maximal inspiratory pressure, indicating improved diaphragm strength.
- Significant decrease in diaphragm motion and activity (sEMG) during breathing, suggesting improved mechanics and reduced effort.
Conclusions:
- EBV treatment significantly enhances diaphragm function in severe emphysema patients.
- The findings highlight the direct physiological link between lung hyperinflation and diaphragm dysfunction.
- Reducing hyperinflation through EBV therapy can partially reverse diaphragm dysfunction.
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