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Nanoplasmonic Biosensors: A Comprehensive Overview and Future Prospects
Chinmaya Mutalik1,2, Shashwat Sharma3, Sibidou Yougbaré4
1Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.
International Journal of Nanomedicine
|May 13, 2025
Summary
Nanoplasmonic biosensors utilize nanomaterials and plasmon resonance for sensitive biomolecule detection in medicine and food safety. Challenges in stability and cost hinder widespread use, but advancements like hybrid nanostructures promise future innovation.
Area of Science:
- Nanotechnology
- Biosensing
- Plasmonics
Background:
- Nanotechnological advancements have led to nanoplasmonic biosensors.
- These sensors use surface plasmon resonance (SPR) and localized SPR (LSPR) phenomena.
- They are crucial for diagnostics in medicine, food safety, and drug discovery.
Purpose of the Study:
- To provide a comprehensive analysis of nanoplasmonic biosensors.
- To emphasize their operational mechanisms, applications, and design.
- To examine challenges and future advancements in the field.
Main Methods:
- Review of nanoplasmonic biosensor principles.
- Analysis of nanomaterial integration (gold, silver).
- Exploration of SPR and LSPR phenomena for detection.
Main Results:
- Nanoplasmonic biosensors enable ultralow concentration biomolecule detection.
- Gold and silver nanomaterials enhance optical and electronic properties.
- Challenges include stability, reproducibility, cost, and scalability.
Conclusions:
- Nanoplasmonic biosensors offer transformative potential in diagnostics.
- Hybrid plasmonic nanostructures are an emerging trend.
- Future innovations focus on miniaturization, automation, and high-throughput analysis.
