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Updated: May 15, 2025

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Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
Published on: February 5, 2015
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Cefepime-induced neurotoxicity
Jessica Taylor1, Hannah M Gunter1, Karen Cohen1
1Division of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Southern African Journal of Infectious Diseases
|May 13, 2025
Summary
Severe cefepime neurotoxicity occurred in a patient with acute kidney injury and infection. Prompt recognition and cefepime withdrawal are vital for managing this serious adverse drug reaction.
Area of Science:
- Pharmacology
- Nephrology
- Infectious Diseases
Background:
- Cefepime is a widely used antibiotic.
- Neurotoxicity is a known, albeit uncommon, adverse effect of cefepime.
- Acute kidney injury can impair cefepime clearance, increasing the risk of neurotoxicity.
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