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Related Experiment Video

Updated: May 15, 2025

Monitoring Acupuncture Effects on Human Brain by fMRI
09:55

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Acupuncture Modulates Spatiotemporal Neuronal Dynamics in Mild Cognitive Impairment: A Protocol for Simultaneous

Ya-Qin Li1,2, Zi-Wen Chen1,3, Hui He4

  • 1School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.

Journal of Multidisciplinary Healthcare
|May 13, 2025
PubMed
Summary

This study investigates if real acupuncture can improve cognitive function in mild cognitive impairment (MCI) by examining brain activity changes. Findings may provide evidence for acupuncture

Keywords:
acupuncturemild cognitive impairmentsimultaneous electroencephalography - functional magnetic resonance imaging

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Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Integrative Medicine

Background:

  • Mild cognitive impairment (MCI) involves altered spatiotemporal neuronal activity.
  • Simultaneous electroencephalogram (EEG)-functional magnetic resonance imaging (fMRI) can measure these changes.
  • Acupuncture's potential to modulate brain activity in MCI is suggested but not fully understood.

Purpose of the Study:

  • To investigate the efficacy of real acupuncture in treating MCI.
  • To elucidate the spatiotemporal neural mechanisms underlying acupuncture's effects in MCI.
  • To provide scientific evidence for acupuncture as a treatment for cognitive impairment.

Main Methods:

  • A 12-week randomized controlled trial with 60 MCI patients.
  • Comparison between real acupuncture (RA) and sham acupuncture (SA) groups.
  • Assessment of cognitive function using ADAS-Cog and specific cognitive domains.
  • Utilizing simultaneous EEG-fMRI with advanced analytical techniques (correlation, regression, jICA).

Main Results:

  • The study aims to determine if real acupuncture modulates spatiotemporal neuronal specificity activity in MCI patients.
  • Expected outcomes include improvements in cognitive function and identification of neural mechanisms.
  • The findings will contribute to understanding acupuncture's role in treating cognitive decline.

Conclusions:

  • Real acupuncture may offer a viable treatment for cognitive impairment in MCI.
  • The study will provide crucial scientific evidence on acupuncture's efficacy and neural basis.
  • This research enhances the understanding of brain modulation through acupuncture for cognitive health.