ALPK1-Dependent cIAP1 Degradation Regulates Helicobacter pylori-Induced Apoptosis
Gunter Maubach1, Michelle C C Lim1, Michael Naumann1
1Medical Faculty, Otto von Guericke University, Institute of Experimental Internal Medicine, Magdeburg, Germany.
Abstract:
Helicobacter pylori infection poses a significant risk for disrupting the gastric epithelium by inducing inflammation and apoptosis. Here, we identify alpha kinase 1 (ALPK1) as essential in H. pylori-induced apoptosis. The absence of ALPK1 leads to the accumulation of cellular inhibitor of apoptosis 1 (cIAP1) upon H. pylori infection, which raises the threshold for the induction of apoptosis. Ablation of cIAP1 with a SMAC-mimetic restores the level of apoptosis induced by H. pylori in these cells. Our findings highlight the impact of ALPK1 on the stability of cIAP1, influencing H. pylori-induced apoptosis.
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