Prostate Adenocarcinoma Recurrence in the Vas Deferens Unveiled by 99m Tc-PSMA SPECT/CT Imaging

Area of Science:

• Nuclear medicine
• Oncology
• Radiopharmacy

Background:

• Prostate cancer recurrence can occur in rare sites like the vas deferens.
• Accurate detection of recurrence is crucial for patient management.
• Access to advanced imaging like 68Ga-PSMA PET/CT is limited in some regions.

Purpose of the Study:

• To evaluate the utility of 99mTc-HYNIC-PSMA SPECT/CT in detecting prostate cancer recurrence.
• To report a case of vas deferens recurrence detected with 99mTc-HYNIC-PSMA SPECT/CT.
• To highlight a cost-effective imaging alternative for recurrent prostate cancer.

Main Methods:

• A 77-year-old male patient with prostate cancer underwent radical prostatectomy.
• After 10 years, elevated PSA prompted investigation.
• 99mTc-HYNIC-PSMA SPECT/CT was performed due to limited PET/CT access.

Main Results:

• Serum PSA levels increased to 2.76 ng/mL, indicating recurrence.
• SPECT/CT revealed PSMA uptake in the bilateral vas deferens.
• This identified a rare site of prostate cancer recurrence.

Conclusions:

• 99mTc-HYNIC-PSMA SPECT/CT can effectively detect vas deferens recurrence in prostate cancer.
• This technique provides a viable alternative to PET/CT in resource-limited settings.
• Further studies are warranted to confirm its broader clinical application.