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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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Cardiovascular disease risk in psoriatic disease: mechanisms and implications for clinical practice

John L Medamana1, Joel M Gelfand2, Brittany N Weber3

  • 1Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York.

Current Opinion in Rheumatology
|May 13, 2025
PubMed

Insights

Psoriasis patients have higher cardiovascular risks due to shared inflammation with atherosclerosis. Managing traditional risk factors and inflammation is key for preventing cardiovascular disease (CVD) in psoriasis.

Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis is an immune-mediated inflammatory skin disease linked to increased cardiovascular disease (CVD) risk, including ischemic heart disease and death.
  • Traditional atherosclerotic cardiovascular disease (ASCVD) risk factors are often underdiagnosed and undertreated in psoriasis patients.

Purpose of the Study:

  • To review the association between psoriasis and cardiovascular disease.
  • To highlight shared inflammatory pathways and discuss prevention strategies.

Main Methods:

  • Literature review of studies investigating psoriasis, inflammation, and cardiovascular outcomes.
  • Analysis of cellular and molecular mechanisms linking psoriasis and atherosclerosis.

Main Results:

  • Psoriasis and atherosclerosis share common inflammatory pathways, including pro-inflammatory cytokines (TNF, IL-6), immune cells, and platelets.
  • These shared pathways contribute to endothelial damage and atherosclerosis progression.

Conclusions:

  • Optimal CVD prevention in psoriasis involves managing traditional ASCVD risk factors.
  • Emerging data suggest that targeting inflammation may further reduce ASCVD risk in psoriasis patients.
Abstract

Keywords:
atherosclerosisinflammationpsoriasis

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