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Related Experiment Video

Updated: Jul 1, 2026

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Published on: April 14, 2022

Modeling Idiopathic Inflammatory Myopathy in the Bioinspired Muscle Tissue on Chip.

Xu Zhang¹, Mengqian Zhao^1,2, Pengwei Deng^3,4

¹Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

Advanced Healthcare Materials

|May 13, 2025

Summary

Researchers developed a vascularized muscle-on-a-chip model to study idiopathic inflammatory myopathies (IIM). This innovative platform mimics IIM

Keywords:

idiopathic inflammatory myopathy modelling monocytes activation skeletal muscle on chip vascularization

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Last Updated: Jul 1, 2026

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

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Published on: April 14, 2022

Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues

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Published on: April 7, 2023

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

Published on: May 5, 2023

Area of Science:

Biomedical Engineering
Immunology
Muscle Physiology

Background:

Idiopathic inflammatory myopathy (IIM) is an autoimmune skeletal muscle disease with unclear pathogenesis due to limited study models.
Existing models struggle to replicate the complex immune-mediated pathology of IIM.

Purpose of the Study:

To develop a novel vascularized muscle tissue model on a chip for studying IIM.
To investigate immune-mediated pathological changes in IIM using this advanced model.

Main Methods:

Constructed a vascularized muscle model via layer-by-layer assembly.
Co-cultured endothelial cells, myoblasts, and monocytes in a perfusable 3D system.
Assessed model biofunctions including cell alignment, fusion, myofiber generation, force production, and biomarker expression.

Main Results:

The model demonstrated functional muscle tissue with proper cell alignment, fusion, myofiber generation, and expression of key muscle biomarkers.
Perfusion with activated monocytes induced myofiber atrophy, inflammatory responses, and reduced muscle maturation markers, mirroring IIM clinical features.
The model successfully recapitulated key pathological aspects of IIM.

Conclusions:

The developed vascularized muscle-on-a-chip platform provides a unique and effective model for studying idiopathic inflammatory myopathies.
This platform offers a promising avenue for advancing myopathies research and facilitating drug testing for IIM.