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Nanozyme-Mediated Joint Homeostasis Restoration: Emerging Strategies for Arthritis Therapy
Shun Han1,2, Daqing Wang1,2, Hyon-U Pak1,2
1Department of Joint Surgery and Sports Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People's Republic of China.
International Journal of Nanomedicine
|July 19, 2026
Summary
Nanozymes offer a promising therapeutic strategy for rheumatoid arthritis (RA), osteoarthritis (OA), and gouty arthritis (GA) by effectively scavenging reactive oxygen species (ROS) and reducing inflammation, overcoming limitations of traditional treatments.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Rheumatology
Background:
- Rheumatoid arthritis (RA), osteoarthritis (OA), and gouty arthritis (GA) are driven by oxidative stress and inflammation.
- Conventional therapies face challenges with toxicity and bioavailability.
- Nanozymes present a novel approach with enhanced stability and tunable ROS scavenging.
Purpose of the Study:
- To review nanozyme-mediated therapeutics for RA, OA, and GA.
- To elucidate disease pathomechanisms and establish therapeutic rationale.
- To analyze barriers to clinical translation of nanozymes.
Main Methods:
- Systematic review of nanozyme applications in arthritis.
- Analysis of nanozyme engineering designs for specific diseases.
- Evaluation of pathomechanisms and therapeutic strategies.
Main Results:
- Nanozymes demonstrate superior physicochemical stability and tunable ROS scavenging.
- Unique advantages include single-atom catalysis, multi-enzyme activity, and prolonged synovial retention.
- A clinical demand-driven classification framework for nanozyme therapeutics is proposed.
Conclusions:
- Nanozymes show significant potential for treating common arthritis types.
- Addressing biosafety, pharmacokinetics, and standardization is crucial for clinical translation.
- Mapping catalytic properties to clinical needs bridges the gap between research and practice.