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Updated: May 16, 2025

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

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[First-trimester screening for pre-eclampsia].

Iben Riishede¹, Martin Overgaard², Henriette Ladegård Skov^3,4

¹Afdeling for Gynækologi, Fertilitet og Fødsler, Københavns Universitetshospital - Rigshospitalet.

Ugeskrift for Laeger

|May 13, 2025

Summary

This summary is machine-generated.

Low-dose aspirin can prevent preterm pre-eclampsia in high-risk pregnancies started before 16 weeks. A new first-trimester screening algorithm predicts pre-eclampsia risk using biophysical, biochemical, and maternal factors.

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Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Pharmacology

Background:

Pre-eclampsia is a significant cause of maternal and fetal morbidity.
Early identification and intervention are crucial for managing pre-eclampsia risk.

Purpose of the Study:

To review the efficacy of low-dose aspirin in preventing preterm pre-eclampsia.
To introduce a novel first-trimester screening algorithm for predicting pre-eclampsia risk.

Main Methods:

Review of existing literature on low-dose aspirin for pre-eclampsia prevention.
Description of a new screening algorithm combining biophysical markers, biochemical markers, and maternal risk factors.
Validation of the screening algorithm internationally and in Denmark.

Main Results:

Low-dose aspirin initiated before 16 weeks of gestation reduces the risk of preterm pre-eclampsia in high-risk women.
The new screening algorithm accurately predicts individual pre-eclampsia risk in the first trimester.
International and Danish validation confirms the algorithm's predictive capability.

Conclusions:

Early initiation of low-dose aspirin is a viable strategy for high-risk pregnancies.
The novel screening algorithm offers a promising tool for early pre-eclampsia risk assessment.
A national implementation project in Denmark will assess the clinical effectiveness of this updated screening strategy.