Modulation of Intraocular Pressure Following Short-Term Periocular Triamcinolone 0.025% in Oculoplastic Surgery

Area of Science:

• Ophthalmology
• Dermatology
• Pharmacology

Background:

• Corticosteroids are known to elevate intraocular pressure (IOP).
• Periocular topical corticosteroids are used for various ocular conditions.
• Understanding the IOP effects of topical periocular triamcinolone acetonide (TA) is crucial.

Purpose of the Study:

• To evaluate the impact of short-term periocular topical TA cream on intraocular pressure (IOP).
• To determine if factors like age, dosage, or concomitant treatments influence IOP changes.
• To assess the safety profile of periocular TA regarding IOP elevation.

Main Methods:

• Retrospective review of 62 patients (120 eyes) treated with periocular 0.025% TA cream.
• Analysis of baseline and follow-up IOP measurements.
• Inclusion of factors: age, dosage, procedure type, application site, and concomitant therapies (TA/5-FU injections, topical steroids).

Main Results:

• Overall mean IOP change was not statistically significant (14.35 to 14.32 mm Hg).
• No significant IOP increase observed with age, once or twice daily dosing, or concomitant treatments.
• Application to bilateral upper eyelids showed a small, statistically significant IOP increase (1.7 mm Hg), but remained within normal limits.

Conclusions:

• Short-term periocular topical TA cream use is not associated with clinically significant IOP elevation.
• The risk of IOP increase appears minimal with limited duration of use.
• Periocular TA demonstrates a favorable IOP safety profile for short-term applications.