Research Progress on BDNF and Depression
Yahong Qiu1, Lixia Zhu2, Wenyan Cai1
1The Key Laboratory of Developmental Genes and Human Disease, Department of Histology and Embryology, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
ACS Chemical Neuroscience
|May 13, 2025
Summary
Depression is linked to imbalances in brain-derived neurotrophic factor (BDNF). Proper conversion of pro-BDNF to mature BDNF is vital for neuronal plasticity and may be key to treating depression.
Area of Science:
- Neuroscience
- Psychiatry
- Molecular Biology
Background:
- Depression is a global health issue impacting millions, causing emotional distress and physical symptoms.
- Brain-derived neurotrophic factor (BDNF) is crucial for central nervous system (CNS) function, particularly in the hippocampus and cortex.
- Dysregulation of pro-BDNF to mature BDNF (mBDNF) conversion is implicated in impaired neuronal plasticity and depression pathogenesis.
Purpose of the Study:
- To comprehensively review the neurotrophic mechanisms involved in depression.
- To explore the role of BDNF, proBDNF, and mBDNF in the pathogenesis of depression.
- To provide a theoretical basis for understanding depression and its clinical treatment.
Main Methods:
- Literature review of studies on BDNF.
- Analysis of BDNF location, expression, and release.
- Examination of the relationship between BDNF forms and depression.
- Review of downstream signaling pathways activated by BDNF receptors.
Main Results:
- Imbalances in proBDNF to mBDNF conversion are associated with impaired neuronal plasticity.
- BDNF plays a significant role in the neurobiological underpinnings of depression.
- Specific signaling pathways activated by BDNF are critical for its function.
Conclusions:
- BDNF dysregulation is a key factor in depression development.
- Understanding BDNF mechanisms offers insights into novel therapeutic strategies for depression.
- Further research into BDNF signaling pathways can advance depression treatment.
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