Proportional Correlation Between Systemic Inflammation Response Index and Gastric Cancer Recurrence Time: A...

Area of Science:

• Oncology
• Medical Statistics

Background:

• Gastric cancer recurrence is a major cause of mortality post-resection.
• Established prognostic factors like TNM staging are insufficient to predict individual recurrence risk.
• Variability in recurrence rates within the same TNM stage necessitates new prognostic markers.

Purpose of the Study:

• To develop and validate a novel prognostic measure for gastric cancer recurrence.
• To assess the practical utility of this new measure in clinical settings.

Main Methods:

• Retrospective analysis of 296 stage II/III gastric cancer patients.
• Patients underwent complete surgical resection and adjuvant chemotherapy.
• Investigated the association between seven variables, including the systemic inflammation response index (SIRI), and cancer recurrence.

Main Results:

• The systemic inflammation response index (SIRI) showed a significant positive correlation with gastric cancer recurrence risk (HR, 1.231; 95% CI, 1.04-1.45).
• Higher SIRI values were significantly associated with a shorter time to recurrence (p = 0.044; β = -0.225).
• Other investigated factors did not demonstrate significant correlations with recurrence.

Conclusions:

• The systemic inflammation response index (SIRI) emerged as a potential independent prognostic factor for gastric cancer recurrence.
• No other effective prognostic factors beyond SIRI were verified in this study.
• SIRI may offer valuable prognostic information for patients with gastric cancer.