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Updated: Feb 9, 2026
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Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of β2 Integrin Activation
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68Ga-Trivehexin: Current Status of αvβ6-Integrin Imaging and Perspectives.
Luca Urso1,2, Rebecca Napolitano3, Giorgia Speltri4
1Department of Translational Medicine, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Cancers
|May 14, 2025
Summary
[68Ga]Ga-Trivehexin is a novel PET imaging probe targeting alpha-v-beta-6 integrin. This advanced tracer shows improved properties and potential for diagnosing cancers and non-cancerous conditions like pulmonary fibrosis.
Area of Science:
- Molecular imaging
- Radiochemistry
- Nuclear medicine
Background:
- Positron emission tomography (PET) has evolved from metabolic tracers like 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) to targeted probes.
- Alpha-v-beta-6 (αvβ6) integrin is a key target in various cancers and non-cancerous diseases.
Purpose of the Study:
- To review the radiochemical properties and clinical applications of the [68Ga]Ga-Trivehexin PET probe.
- To assess advancements and challenges in αvβ6-integrin targeted molecular imaging.
Main Methods:
- Systematic literature review of preclinical and clinical studies on [68Ga]Ga-Trivehexin.
- Emphasis on radiochemical characteristics, pharmacokinetic properties, and clinical utility.
Main Results:
- Optimized multimeric [68Ga]Ga-Trivehexin shows 18-fold improved binding affinity and selectivity for αvβ6 integrin compared to monomeric tracers.
- High radiochemical purity (>95%) achieved, suitable for clinical use.
- Promising preliminary results in head and neck cancer, pancreatic cancer, idiopathic pulmonary fibrosis, and primary hyperthyroidism, outperforming [18F]FDG in some cases.
Conclusions:
- [68Ga]Ga-Trivehexin is a promising PET probe for imaging αvβ6-integrin.
- Demonstrates potential in both oncological and non-oncological diseases, including idiopathic pulmonary fibrosis and primary hyperparathyroidism.
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