Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1.

Molecular therapy. Oncology·2024
Same author

Green Chemistry for Biomimetic Materials: Synthesis and Electrospinning of High-Molecular-Weight Polycarbonate-Based Nonisocyanate Polyurethanes.

ACS omega·2022
Same author

Photo-Curing Kinetics of 3D-Printing Photo-Inks Based on Urethane-Acrylates.

Polymers·2022
Same author

Synthesis and Characterization of Catechol-Containing Polyacrylamides with Adhesive Properties.

Molecules (Basel, Switzerland)·2022
Same author

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application.

Journal of visualized experiments : JoVE·2019
Same author

Author Correction: 3D biodegradable scaffolds of polycaprolactone with silicate-containing hydroxyapatite microparticles for bone tissue engineering: high-resolution tomography and in vitro study.

Scientific reports·2018

Related Experiment Video

Updated: Jul 15, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

28.7K

Photocurable Crosslinker from Bio-Based Non-Isocyanate Poly(hydroxyurethane) for Biocompatible Hydrogels.

Kathleen Hennig1, Gabriele Vacun2, Sibylle Thude3

  • 1Department of Life Science and Bioprocesses, Fraunhofer Institute for Applied Polymer Research IAP, Geiselbergstr. 69, 14476 Potsdam-Golm, Germany.

Polymers
|May 14, 2025
PubMed
Summary

This study synthesized eco-friendly, photocurable polyhydroxyethylurethanes (BPHUs) from renewable sources for biomedical uses. The resulting materials show good cell viability and tunable properties for applications like medical devices.

Keywords:
cytocompatibilitygreen chemistrynon-isocyanate polyurethanephotoreactive crosslinkers

More Related Videos

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

16.6K
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.3K

Related Experiment Videos

Last Updated: Jul 15, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

28.7K
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

16.6K
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.3K

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Green Chemistry

Background:

  • Traditional polyurethanes often involve toxic isocyanates.
  • There is a growing demand for sustainable and biocompatible materials in the medical field.
  • Developing light-curable polymers from renewable resources is crucial for advanced biomedical applications.

Purpose of the Study:

  • To synthesize photocurable non-isocyanate polyhydroxyethylurethanes (BPHUs) from renewable feedstocks.
  • To develop both aliphatic and aromatic BPHU variants for diverse biomedical applications.
  • To evaluate the properties and biocompatibility of the synthesized BPHUs for potential use in medical devices.

Main Methods:

  • Two synthetic routes were established: an aliphatic pathway using 1,4-butanediol-derived cyclic carbonates and an aromatic pathway using resorcinol-based carbonates.
  • Ring-opening polymerization with dodecanediamine followed by methacrylation yielded photoreactive BPHU derivatives.
  • Characterization involved NMR, GPC, and FTIR; UV curing produced hydrogels, and swelling properties were assessed. Cytotoxicity was evaluated per DIN EN ISO 10993-5.

Main Results:

  • Successful synthesis of aliphatic and aromatic BPHU intermediates and their methacrylated derivatives was confirmed.
  • UV curing resulted in hydrogels with significant swelling: aliphatic BPHUs (91.3% gel content, 1057% swelling) and aromatic BPHUs (78.1% gel content, 3304% swelling).
  • Both BPHU variants exhibited non-cytotoxicity, with >80% cell viability, indicating suitability for biomedical applications.

Conclusions:

  • Renewable-source-based BPHUs offer a versatile and eco-friendly alternative to conventional polyurethanes.
  • The tunable mechanical properties (flexibility vs. rigidity) make these BPHUs suitable for a range of biomedical applications, from adaptable implants to load-bearing devices.
  • This research highlights the potential of green chemistry in developing advanced, biocompatible materials for next-generation medical devices.