Otolaryngological Problems Among Patients with Growth Hormone Deficiency-A Systematic Review

Area of Science:

• Endocrinology
• Otorhinolaryngology

Background:

• Growth hormone deficiency (GHD) is a rare endocrine disorder impacting growth and physiological functions.
• GHD is linked to various otorhinolaryngological (ENT) symptoms, including hearing loss and dizziness.
• These ENT symptoms are often underrecognized in GHD patient care.

Purpose of the Study:

• To systematically review the prevalence of ENT symptoms in patients diagnosed with GHD.
• To highlight the association between GHD and specific otorhinolaryngological manifestations.

Main Methods:

• Systematic review adhering to PRISMA guidelines.
• Analysis of studies from PubMed, Embase, and Scopus databases.
• Inclusion of eleven studies meeting predefined criteria.

Main Results:

• Over 61% of patients with GHD experience ENT symptoms.
• Symptom prevalence varies with treatment access, age of onset, and comorbidities.
• Routine ENT assessments are vital for comprehensive GHD management.

Conclusions:

• Early detection and management of ENT symptoms in GHD patients can enhance quality of life.
• Addressing ENT issues may mitigate social and educational challenges for GHD patients.
• Further research is needed on growth hormone therapy's role in ENT symptom management.