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Published on: November 9, 2016
Botulinum Toxin Type A Injection Near the Stylomastoid Foramen: A Safe and Effective Therapeutic Modality for
Lingxi Zhu1, Lizhen Pan1, Xiaolong Zhang1
1Neurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University.
Objective:
This study aimed to assess the efficacy and safety of botulinum toxin type A (BTX-A) injection near the stylomastoid foramen for tinnitus in patients with hemifacial spasm (HFS).
Study Design:
Retrospective study from 2011 to 2024.
Setting:
Tongji Hospital affiliated to Tongji University in Shanghai, China.
Patients:
Patients with HFS combined with tinnitus.
Intervention:
BTX-A injection near the stylomastoid foramen.
Main Outcome Measures:
The efficacy of BTX-A was assessed based on subjective improvement reported by patients after 1 month. Adverse events were also documented.
Results:
A total of 869 HFS patients were analyzed, including 122 with tinnitus. Among the 122 patients with tinnitus, 110 received BTX-A injections near the stylomastoid foramen, and complete follow-up data were available for 105 of them. The 3.75 U group showed a higher improvement rate (69.2 ± 14.3%) compared with the 2.5 U group (46.3 ± 25.0%, p < 0.05). The majority received a 5 U dose, with a significantly higher improvement rate (76.9 ± 15.1%) compared with the 2.5 U group ( p < 0.01). All reported adverse events were related to routine injection sites and were mild, requiring no special treatment. No adverse events related to BTX-A injection near the stylomastoid foramen were reported.
Conclusion:
In patients with HFS-associated tinnitus, additional injection of 5 U BTX-A near the stylomastoid foramen, targeting the stapedius muscle, proved to be an effective therapy with minimal adverse effects.
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