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Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

222
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
222

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Engineered Tissue Models to Decode Host-Microbiota Interactions.

Miryam Adelfio1, Grace E Callen1, Xuesong He2

  • 1Department of Biomedical Engineering, University of Massachusetts-Lowell, Lowell, MA, 01854, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 14, 2025
PubMed
Summary
This summary is machine-generated.

Host-associated microbiota maintain health, but dysbiosis can cause disease. This review explores in vitro models for studying host-microbiota interactions and developing new therapies.

Keywords:
dysbiosisfemale reproductive tracthost‐microbiome interactionsintestineoralskintissue models

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Area of Science:

  • Microbiology
  • Human Physiology
  • Disease Pathogenesis

Background:

  • The human body hosts a symbiotic relationship with its microbiota, crucial for local tissue function and overall organismal well-being.
  • Alterations in microbiota composition, termed dysbiosis, disrupt host interactions and can lead to disease, even affecting distant organs.
  • Understanding the mechanisms of dysbiosis is key to restoring tissue homeostasis and preventing disease.

Purpose of the Study:

  • To review current in vitro host-microbiota research strategies.
  • To provide a roadmap for developing advanced in vitro models of ecological niches.
  • To highlight emerging in vitro approaches for therapeutic development and validation.

Main Methods:

  • Survey of existing literature on in vitro host-microbiota research.
  • Analysis of strategies for creating physiologically relevant in vitro models.
  • Examination of emerging technologies supporting therapeutic validation.

Main Results:

  • In vitro models offer high-fidelity platforms for studying niche-specific host-microbiota interactions.
  • Physiologically relevant in vitro models are essential for investigating microbiota's role in health and disease.
  • Emerging in vitro strategies align with regulatory advancements for therapy development.

Conclusions:

  • Advanced in vitro models are critical for dissecting the complex host-microbiota interplay.
  • Developing these models will enhance our understanding of dysbiosis and its pathologies.
  • In vitro research is pivotal for accelerating the validation and market entry of novel therapies.