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Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
Published on: August 4, 2017
Advances in hydrogel research: a 25-year bibliometric overview
Dongbin Zhang1, Mengru Qiu2, Yu Tian3
1Department of Special Inspection, Shandong Academy of Occupational Health and Occupational Medicine, Occupational Disease Hospital of Shandong First Medical University (Shandong Province Hospital Occupational Disease Hospital), Jinan, Shandong, China.
This bibliometric analysis reveals significant growth in hydrogel research, with China leading publications and the US leading citations. Key themes diversify from material science to tissue engineering and drug delivery.
Area of Science:
- Multidisciplinary research spanning Physical Sciences, Life Sciences, and Health Sciences.
Background:
- Hydrogel research has experienced exponential growth from 2000 to 2024.
- Significant portion (37%) of hydrogel research is open access, promoting wider dissemination.
Purpose of the Study:
- To provide a comprehensive bibliometric analysis of hydrogel research from 2000-2025.
- To map the evolution, trends, and impact of hydrogel research globally.
Main Methods:
- Bibliometric analysis of 101,291 publications from the OpenAlex database.
- Citation analysis to identify high-impact research.
- Network analysis for international collaborations.
- Latent Dirichlet Allocation (LDA) for topic modeling.
Main Results:
- Research output surged from ~350 publications in 2000 to nearly 11,000 in 2024.
- China leads in publication volume (27,931), while the US leads in citation impact (>1 million).
- Top 1% of papers account for 20% of all citations, indicating concentrated impact.
- 17 distinct research themes identified, showing diversification into advanced applications.
Conclusions:
- Hydrogel research is a rapidly expanding and diversifying field.
- International collaborations, particularly between the US and China, are increasing.
- Emerging research focuses on tissue engineering, drug delivery, and regenerative medicine, offering future innovation opportunities.
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