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Updated: May 16, 2025
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
CXCR4-Targeted Imaging in Takayasu Arteritis Using 68 Ga-Pentixafor PET/CT
Thorsten Derlin1, Torsten Witte2
1Departments of Nuclear Medicine.
None:
We report a case of a 64-year-old woman with Takayasu arteritis who underwent chemokine receptor CXCR4-targeted whole-body 68 Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) for further evaluation of disease activity and exclusion of concurrent inflammatory diseases. 68 Ga-Pentixafor PET demonstrated CXCR4-positive inflammatory cell infiltrates in the aortic wall, and active disease was further confirmed by 18 F-fluorodeoxyglucose (FDG) PET/CT. Moreover, 68 Ga-Pentixafor identified a CXCR4-positive pelvic bone lesion, and the patient was subsequently diagnosed with diffuse large B-cell lymphoma. CXCR4-targeted 68 Ga-Pentixafor PET is useful for the detection of active inflammation in Takayasu arteritis, and to detect neoplastic disease in this cohort with increased risk of malignancy.
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