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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Updated: May 16, 2025

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Topical timolol for calciphylaxis: a case report.

Lamis Elyamani1, Ouissal Hormi1, Nada Benaini1

  • 1Mohammed VI University Hospital of Oujda, Medical School of Oujda, Mohammed First University of Oujda, Oujda, Morocco.

Wounds : a Compendium of Clinical Research and Practice
|May 14, 2025
PubMed
Summary
This summary is machine-generated.

Topical timolol effectively treated calciphylaxis ulcers in a chronic kidney disease patient, promoting rapid wound healing and pain relief. This novel approach shows promise for managing this rare, severe skin condition.

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Area of Science:

  • Dermatology
  • Nephrology
  • Vascular Medicine

Background:

  • Calciphylaxis is a rare, severe skin disease causing painful ulcers and necrosis due to vascular thrombosis and calcification.
  • Effective treatments for calciphylaxis are limited, contributing to high morbidity and mortality rates.

Purpose of the Study:

  • To report a novel therapeutic approach for calciphylaxis ulcers.
  • To evaluate the efficacy of topical timolol in managing calciphylaxis.

Main Methods:

  • A case study of a 65-year-old female with chronic kidney disease and calciphylaxis.
  • Diagnosis confirmed by clinical examination and imaging.
  • Treatment involved topical timolol application to ulcers.

Main Results:

  • Successful treatment of painful bilateral calciphylaxis ulcers with topical timolol.
  • Rapid wound healing and significant pain reduction observed.
  • Clinical and imaging data supported treatment effectiveness.

Conclusions:

  • Topical timolol demonstrates potential as a novel treatment for calciphylaxis-related skin ulcers.
  • This approach offers a promising new avenue for improving patient outcomes in calciphylaxis.
  • Further research is needed to validate topical timolol's efficacy in larger studies.