A novel multifunctional self-assembled nanocellulose based scaffold for the healing of diabetic wounds

The healing of chronic diabetic wounds remains a key challenge due to its susceptibility to bacterial infection, the inflammatory wound microenvironment, and difficulty in angiogenesis. Herein, we devised a smart scaffold of nanocellulose with silk fibroin-loaded cerium oxide nanoparticles for the treatment of diabetic wounds. The smart scaffold dressing displays excellent porosity, water absorption, air permeability, water retention, controlled degradability, and antioxidant properties. In vitro experiments demonstrated that the scaffold was capable of promoting the degradation of the scaffolds through uncross linking and exhibited antibacterial activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria. Furthermore, in vivo experiments showed that smart scaffold dressing can reduces inflammation at the wound site of diabetic mice and promote collagen deposition, angiogenesis and re-epithelialization during wound healing in diabetic mice, exhibiting favorable biocompatibility and biodegradability. Its efficacy surpassed that of the current commercially available membrane dressings (3 M dressings) and medical PELNAC dressings (Class III medical device). These findings suggest that the smart scaffold dressing is a promising and innovative dressing for the treatment of diabetic wounds.