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Related Experiment Video

Updated: Jun 16, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

The microglial lineage: present and beyond.

Wei-Wei Chen¹, Zhisheng Wu¹, Hanjie Li²

¹Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Trends in Immunology

|May 14, 2025

Summary

This summary is machine-generated.

Researchers propose the term "microglial lineage" for cells sharing features with classical microglia found in peripheral tissues. These cells represent a diverse group of resident immune cells with varied functions across different body locations.

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Last Updated: Jun 16, 2025

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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Area of Science:

Immunology
Cell Biology
Neuroscience

Background:

Recent research indicates the presence of microglial-like cells in various peripheral tissues beyond the central nervous system.
Classical microglia are well-established as the resident immune cells of the brain.

Purpose of the Study:

To introduce and define a unifying term, "microglial lineage," to encompass both classical microglia and similar cells found in peripheral tissues.
To establish a framework for understanding the broader distribution and functional diversity of microglial-related cells.

Main Methods:

Literature review and synthesis of emerging data on tissue-resident immune cells.
Comparative analysis of molecular phenotypes and ontogeny of central and peripheral immune cells.

Main Results:

Identification of cells with microglial molecular signatures and developmental origins in multiple peripheral organs.
Recognition of functional heterogeneity among these microglial lineage cells depending on their tissue environment.

Conclusions:

The proposed "microglial lineage" term provides a cohesive classification for these immune cells.
Understanding microglial lineage cells is crucial for comprehending tissue immunity and homeostasis across the body.