Related Experiment Video
Updated: Jun 19, 2026
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
The Uric Acid to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in
Ryotaro Yamamoto1, Yukihiro Fukuda1, Takafumi Kawaguchi1
1Department of Cardiovascular Medicine, Hiroshima Prefectural Hospital.
Insights
The uric acid-to-high-density lipoprotein cholesterol ratio is linked to impaired left ventricular diastolic function in patients without significant perfusion issues. This inflammatory marker may impact heart diastolic parameters, as shown by gated SPECT imaging.
Area of Science:
- Cardiology
- Biochemistry
- Medical Imaging
Background:
- The uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio is recognized as an inflammation marker.
- The association between this UA-to-HDL-C ratio and left ventricular (LV) diastolic function is not well-established.
- This study investigates the relationship between the UA-to-HDL-C ratio and LV diastolic parameters in patients without significant perfusion abnormalities.
Purpose of the Study:
- To test the hypothesis that the UA-to-HDL-C ratio is associated with LV diastolic parameters.
- To evaluate LV diastolic function using gated myocardial perfusion single-photon emission computed tomography (SPECT).
- To identify potential associations in patients with preserved ejection fraction and no significant perfusion defects.
Main Methods:
- Gated SPECT was used to derive LV diastolic parameters, including peak filling rate (PFR) and one-third mean filling rate (1/3 MFR).
- Serum UA and plasma HDL-C levels were measured in 204 patients.
- Multivariate linear regression analysis was performed to identify factors associated with diastolic parameters.
Main Results:
- The UA-to-HDL-C ratio showed significant inverse associations with both PFR (r = -0.20; P = 0.005) and 1/3 MFR (r = -0.17; P = 0.018).
- Multivariate analysis confirmed that the UA-to-HDL-C ratio was independently associated with PFR (β = -0.17; P = 0.023) and 1/3 MFR (β = -0.14; P = 0.047).
- Age and LV volumes/mass were also significant independent predictors for diastolic parameters.
Conclusions:
- The UA-to-HDL-C ratio is significantly associated with impaired LV diastolic function in patients without significant perfusion abnormalities.
- This inflammatory marker may serve as a non-invasive indicator of subclinical diastolic dysfunction.
- Gated SPECT is a valuable tool for assessing LV diastolic parameters in relation to metabolic markers.
Abstract:
The ratio of uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) is a marker of inflammation. However, whether this ratio is associated with left ventricular (LV) diastolic function remains unknown. This study tested the hypothesis that the UA-to-HDL-C ratio is associated with LV diastolic parameters derived from gated myocardial perfusion single-photon emission computed tomography (SPECT) in patients with no significant perfusion abnormalities.The study population included 204 patients with no significant perfusion abnormalities and a preserved ejection fraction. The peak filling rate (PFR) and one-third mean filling rate (1/3 MFR) were obtained as LV diastolic parameters using gated SPECT. Serum UA and plasma HDL-C levels were also examined.Significant associations were observed between the UA-to-HDL-C ratio and the PFR (r = -0.20; P = 0.005) and 1/3 MFR (r = -0.17; P = 0.018). Multivariate linear regression analysis was performed to determine the factors associated with LV diastolic parameters. Age (β = -0.13; P = 0.046), the LV end-diastolic volume (β = -0.17; P = 0.046), and the UA-to-HDL-C ratio (β = -0.17; P = 0.023) were significantly associated with the PFR. Moreover, age (β = -0.18; P = 0.011), the LV mass index (β = -0.19; P = 0.011), and the UA-to-HDL-C ratio (β = -0.14; P = 0.047) were significantly associated with the 1/3 MFR.These results demonstrated that the UA-to-HDL-C ratio is associated with LV diastolic function derived from gated SPECT in patients with no significant perfusion abnormalities.
More Related Videos
12:12Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
