Advanced Oxidation Protein Products in Obstructive Sleep Apnea Hypopnea Syndrome-A Systematic Review and...

Area of Science:

• Biochemistry
• Sleep Medicine
• Oxidative Stress Research

Background:

• Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep disorder.
• Previous research suggests a link between OSAHS and oxidative stress biomarkers like advanced oxidation protein products (AOPP).
• The exact relationship between AOPP levels and OSAHS requires further clarification.

Purpose of the Study:

• To systematically review and quantitatively synthesize evidence on the association between AOPP levels and OSAHS.
• To assess the role of AOPP as a potential biomarker in OSAHS.

Main Methods:

• A comprehensive literature search was conducted across multiple databases up to October 2023.
• Nine studies involving 608 OSAHS patients and 770 controls were included after screening.
• Statistical analysis, including meta-analysis and meta-regression, was performed using standardized mean differences (SMDs).

Main Results:

• The meta-analysis revealed significantly elevated AOPP concentrations in OSAHS patients compared to controls (SMD = 1.66).
• Meta-regression indicated that publication year and BMI were significantly associated with effect sizes.
• Elevated levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were also observed in OSAHS patients.

Conclusions:

• This meta-analysis confirms substantially higher AOPP concentrations in OSAHS patients.
• The findings suggest that AOPP plays a role in the pathogenesis of OSAHS.
• AOPP may serve as a valuable biomarker for future clinical research in OSAHS.