Atorvastatin-Associated Acute Pancreatitis: A Case Report.

Area of Science:

• Gastroenterology
• Pharmacology

Background:

• Acute pancreatitis (AP) is a serious condition where pancreatic enzymes activate prematurely.
• While statin-induced pancreatitis is uncommon, it warrants investigation due to potential medication avoidance benefits.
• Conflicting evidence exists regarding the association between statin use and AP risk.

Purpose of the Study:

• To report a case of acute pancreatitis potentially caused by atorvastatin.
• To emphasize the importance of considering statins as a potential etiology for AP in patients with dyslipidemia.

Main Methods:

• A case report of a 48-year-old male patient with dyslipidemia treated with atorvastatin.
• Clinical presentation, laboratory findings (elevated lipase, amylase, ALT), and diagnostic workup for AP were documented.
• Atorvastatin was identified as the probable cause and subsequently discontinued.

Main Results:

• The patient developed acute pancreatitis with characteristic symptoms and laboratory markers.
• Other common causes of AP, including alcohol and tobacco use, were ruled out.
• Discontinuation of atorvastatin led to supportive care and patient recovery, strengthening the etiological link.

Conclusions:

• This case suggests a potential link between atorvastatin use and the development of acute pancreatitis.
• Careful monitoring for AP symptoms in patients on statin therapy is crucial.
• Documenting such rare adverse events contributes to understanding the full spectrum of statin-related risks.