Related Experiment Video
Updated: May 16, 2025
04:12
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
Published on: January 19, 2024
741
Margarita (Pearl) Extract Alleviates Melasma by Targeting CAMP-Responsive Element Binding Protein 1
1Department of Dermatology, Zhejiang Provincial Dermatology Hospital, Huzhou, China.
Journal of Cosmetic Dermatology
|May 15, 2025
Summary
Pearl effectively treats melasma by regulating the CREB1/MITF pathway, impacting TYR and DCT genes. This natural compound offers a promising therapeutic approach for melasma management.
Area of Science:
- Dermatology
- Traditional Chinese Medicine
- Molecular Biology
Background:
- Melasma is a common skin condition characterized by hyperpigmentation.
- Pearl possesses known detoxifying and skin barrier-repairing properties.
- The therapeutic potential of pearl for melasma requires further investigation.
Purpose of the Study:
- To evaluate the therapeutic effect of pearl on melasma.
- To explore the potential mechanism of action of pearl in treating melasma.
Main Methods:
- Clinical evaluation using Melasma Area and Severity Index (MASI) and Physician's Global Assessment (PGA) scores.
- DNA sequencing to identify melasma-related genes.
- Database mining for pearl's active compounds and targets.
- KEGG pathway analysis and in vitro verification using human melanoma cells.
Main Results:
- Pearl significantly improved MASI and PGA scores in melasma patients.
- TYR and DCT were identified as melasma-related genes.
- Pearl targets CREB1, regulating the CREB1/MITF axis to affect TYR and DCT, thereby inhibiting melanoma cell activity and tyrosinase.
- Active compounds in pearl include calcium carbonate, iron, magnesium, manganese, silicon, strontium, and zinc.
Conclusions:
- Pearl alleviates melasma by targeting the CREB1/MITF axis.
- This mechanism impacts melasma-related genes TYR and DCT.
- Pearl demonstrates therapeutic potential for melasma through its effects on key molecular pathways.
Related Concept Videos
01:19Management of Insomnia
223
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
223
01:19Pigmentation
2.2K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.2K