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Molecularly Imprinted Polymers Coupled with Cellulosic Paper-Based Analytical Devices for Biosensing Applications.

Ashish Kapoor1, Muthukumar Raghunathan2, Praveen Kumar2

  • 1Department of Chemical Engineering, Harcourt Butler Technical University, Kanpur, Uttar Pradesh India.

Indian Journal of Microbiology
|May 15, 2025
PubMed
Summary
This summary is machine-generated.

Molecularly imprinted polymers (MIPs) integrated with paper-based analytical devices (PADs) offer a powerful platform for selective on-site detection. These MIP-PADs provide affordable, portable, and disposable solutions for various analytical challenges.

Keywords:
Biomedical diagnosticsEnvironmental and food analysisMIPsMicrofluidicsPaper-based analytical devices

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Molecularly imprinted polymers (MIPs) mimic biomolecular receptors for selective analyte recognition in biosensing.
  • Paper-based analytical devices (PADs) offer a low-cost, portable, and disposable platform for chemical and biological analysis.
  • Integrating MIPs with PADs (MIP-PADs) enhances selectivity and enables on-site detection in complex samples.

Purpose of the Study:

  • To review advances in the fabrication of MIP-PADs.
  • To explore the diverse applications of MIP-PADs in various detection formats.
  • To discuss the challenges and future prospects of MIP-PAD technology.

Main Methods:

  • Synthesis of MIPs tailored for specific target analytes.
  • Incorporation of MIPs into cellulosic paper substrates to create MIP-PADs.
  • Utilizing various detection mechanisms including colorimetric, fluorometric, chemiluminescent, electrochemical, photoelectrochemical, and surface-enhanced Raman spectroscopy.

Main Results:

  • MIP-PADs demonstrate high selectivity and sensitivity for detecting biomolecules, pathogens, and small molecules.
  • Fabrication yields affordable, portable, and disposable analytical devices.
  • MIP-PADs are suitable for on-site detection in environmental monitoring, food safety, and biomedical analysis.

Conclusions:

  • MIP-PADs represent a promising technology for accessible and effective on-site analysis.
  • Their cost-effectiveness and user-friendliness make them ideal for resource-limited settings.
  • Further development is needed to address challenges for widespread real-world application.