Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Study of Techniques for Restoring Function in Thrombotically Occluded Peripherally Inserted Central Catheters: An In Vitro Model Study.

Journal of infusion nursing : the official publication of the Infusion Nurses Society·2026
Same author

Protocol for prognosticating PPD using EEG changes during labor pain by uterine contractions: a prospective cohort study in the first stage of labor.

BMC pregnancy and childbirth·2025
Same author

Monocyte-Derived Macrophages Aggravate Cardiac Dysfunction After Ischemic Stroke in Mice.

Journal of the American Heart Association·2024
Same author

Inhibition of PARP1 improves cardiac function after myocardial infarction via up-regulated NLRC5.

Chemico-biological interactions·2024
Same author

Decreased connexin 40 expression of the sinoatrial node mediates ischemic stroke-induced arrhythmia in mice.

Experimental neurology·2024
Same author

Role of galectin-3 in cardiac dysfunction induced by subarachnoid hemorrhage.

Experimental neurology·2023

Related Experiment Video

Updated: May 16, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

8.7K

Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters.

Feng-Xian Li1,2, Qiao-Hong Guo1

  • 1College of Nursing, Capital Medical University, Beijing, China.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|May 15, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a reliable model for thrombotic catheter occlusion in peripherally inserted central catheters (PICC). This simulation accurately reflects real-world catheter occlusion and aids research into recanalization therapies.

Keywords:
PICC occlusionmodelperipherally inserted central catheter

More Related Videos

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

356
Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model
09:05

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model

Published on: January 30, 2015

71.7K

Related Experiment Videos

Last Updated: May 16, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

8.7K
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

356
Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model
09:05

Catheterization of the Carotid Artery and Jugular Vein to Perform Hemodynamic Measures, Infusions and Blood Sampling in a Conscious Rat Model

Published on: January 30, 2015

71.7K

Area of Science:

  • Biomedical Engineering
  • Medical Device Research
  • Vascular Access Devices

Background:

  • Catheter occlusion is a common complication in clinical practice.
  • Peripherally inserted central catheters (PICCs) are widely used, making their occlusion a significant issue.
  • Existing models for studying catheter occlusion are limited.

Purpose of the Study:

  • To simulate thrombotic occlusion in PICCs.
  • To develop a reliable and reproducible model for catheter occlusion.
  • To provide a framework for research on catheter occlusion and recanalization.

Main Methods:

  • Sterile anticoagulant bovine blood was injected into PICC models.
  • Catheter tips were clamped and incubated for 72 hours to induce thrombosis.
  • Diagnostic methods included syringe withdrawal and infusion pump alarms.

Main Results:

  • A 100% success rate in producing intra-catheter thrombus.
  • An 84.29% success rate in modeling catheter occlusion, confirmed by lack of blood reflux and infusion pump alarms.
  • High correlation (90.71% and 90%) between syringe withdrawal and infusion pump alarms in diagnosing occlusion.

Conclusions:

  • The developed model reliably simulates key characteristics of thrombotic catheter occlusion.
  • This model offers a valuable tool for investigating catheter occlusion mechanisms.
  • The simulation has potential for future clinical research and application.