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Related Experiment Video

Updated: Mar 1, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
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Comparative Study of Techniques for Restoring Function in Thrombotically Occluded Peripherally Inserted Central

Feng-Xian Li1, Peng Su, Yue-Bing Li

  • 1Author Affiliations: Department of Oncology, Teaching Hospital of Capital Medical University, Beijing Shijingshan Hospital, Beijing, People's Republic of China (F.-X. Li, Y.-B. Li, H.-W. Li, and H.-H. Gao); Department of Orthopedics, Teaching Hospital of Capital Medical University, Beijing Shijingshan Hospital, Beijing, People's Republic of China (Su).

Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

The intermittent negative-pressure guidewire technique is more effective at restoring function in blocked peripherally inserted central catheters (PICCs) than the stay-locking technique, showing higher success rates and faster operation times.

Keywords:
PICCguidewirein vitro modelintermittent negative pressurethrombotic occlusion

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Area of Science:

  • Vascular Access Devices
  • Interventional Radiology
  • Catheter Patency Maintenance

Background:

  • Thrombotic occlusion frequently impedes the function of peripherally inserted central catheters (PICCs).
  • Restoring PICC function is crucial for continued patient therapy and avoiding catheter replacement.

Purpose of the Study:

  • To compare the efficacy, safety, and operational efficiency of two techniques for clearing thrombi from occluded PICCs.
  • Evaluate the intermittent negative-pressure guidewire technique against the stay-locking technique in an in vitro model.

Main Methods:

  • An in vitro model of thrombotically occluded PICCs was established.
  • 90 occluded PICCs were randomized into two groups: intermittent negative-pressure guidewire technique (n=43) and stay-locking technique (n=45).
  • Procedural data including success rate, thrombus overflow, operation time, and pressure recovery were collected and analyzed.

Main Results:

  • The intermittent negative-pressure guidewire technique achieved a significantly higher success rate (62.79%) compared to the stay-locking technique (4.44%).
  • Successful interventions with the negative-pressure technique were associated with shorter operation times and higher pressure recovery rates.
  • While thrombus overflow incidence was similar, the length of overflow was greater in the control group.

Conclusions:

  • The intermittent negative-pressure guidewire technique is superior for restoring function in thrombotically occluded PICCs compared to the stay-locking technique.
  • This technique offers improved efficacy, evidenced by higher success rates and reduced operation times.
  • The significant pressure recovery indicates effective restoration of catheter function.