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Barriers to Chimeric Antigen Receptor T-Cell Therapy

Yannis K Valtis1,2, Kuo-Kai Chin2, David Nemirovsky3

  • 1Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

JAMA Oncology
|May 15, 2025
PubMed
Summary

No abstract available in PubMed .

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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