Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Transcription

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...

Epistasis

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...

Epistasis Analysis

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...

Gene-Environment Interactions

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

Regulation of Expression at Multiple Steps

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-Cost and Scalable Flexible Infrared Detectors Based on VO<sub>2</sub>(B) Nano-Ink: From Single-Device Sensing to Array Imaging.

ACS applied materials & interfaces·2026

Same author

Non-destructive detection of multiple fatty acids in fuzzy cottonseeds based on near-infrared spectroscopy and chemometrics.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026

Same author

SpatioTemporal Omics Consortium: a global effort for biological discovery across species, space and time.

Nature methods·2026

Same author

HO-1 alleviates lipopolysaccharide-induced acute lung injury in mice by downregulating TFE3 expression and nuclear translocation and suppressing Golgi stress response.

International immunopharmacology·2026

Same author

hsa-miR-375-3p in embryo culture medium exosomes as a preimplantation non-invasive biomarker for predicting live birth after IVF.

Reproductive biomedicine online·2026

Same author

Multimodal MRI reveals microstructural and macrostructural alterations in Parkinson's disease: A combined 3D structural and NODDI study.

Magnetic resonance imaging·2026

Search research articles

Related Experiment Video

Updated: May 17, 2025

CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells

CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells

Published on: May 25, 2018

Epitranscriptome-epigenome interactions in development and disease mechanisms.

Chengyu Li¹, Kexuan Chen¹, Xiaoyu Li²

¹The Second Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; State Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311121, China.

Trends in Genetics : TIG

|May 15, 2025

Summary

This summary is machine-generated.

The epigenome and epitranscriptome communicate through cis and trans modes, influencing development and disease. Understanding this crosstalk is crucial for future research in complex genetic disorders and cancer.

Keywords:

RNA modification epigenetic crosstalk epigenome gene regulation

More Related Videos

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Purification of Transcripts and Metabolites from Drosophila Heads

Purification of Transcripts and Metabolites from Drosophila Heads

Published on: March 15, 2013

Related Experiment Videos

Last Updated: May 17, 2025

CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells

CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells

Published on: May 25, 2018

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Purification of Transcripts and Metabolites from Drosophila Heads

Purification of Transcripts and Metabolites from Drosophila Heads

Published on: March 15, 2013

Area of Science:

Molecular Biology
Genetics
Epigenetics

Background:

Epitranscriptomic RNA modifications and epigenomic DNA/histone modifications are vital in biological processes.
Crosstalk between these layers is increasingly recognized as fundamental in development and disease.

Purpose of the Study:

To summarize the major regulatory modes of epigenome-epitranscriptome crosstalk.
To explore the functional roles of this crosstalk in physiological and pathological contexts.

Main Methods:

Literature review and synthesis of existing research on epigenome-epitranscriptome interactions.
Categorization of crosstalk into 'cis' and 'trans' modes based on regulatory mechanisms.

Main Results:

Identified two primary modes of crosstalk: 'cis mode' (co-transcriptional, direct interactions) and 'trans mode' (indirect regulation via writers/erasers).
Highlighted the involvement of this crosstalk in development, differentiation, cancer, and complex genetic diseases.

Conclusions:

Epigenome-epitranscriptome crosstalk is a key regulatory mechanism with significant implications for health and disease.
Further systematic investigation is needed to fully elucidate these interactions and their therapeutic potential.