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Updated: Jun 18, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
09:13

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure

Conner J Langeberg1,2, Matthew J Szucs1, Madeline E Sherlock1,3

  • 1Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Nature Communications
|May 15, 2025
PubMed
Summary

Flaviviruses use structured RNAs called xrRNAs to resist degradation by host enzymes. This study reveals a unique xrRNA structure in Powassan Virus, a tick-borne pathogen, highlighting a conserved strategy for viral RNA protection.

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