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Platelet Rich Products in Cleft Palate Repair

Samer T Elsamna1, Fayssal Alqudrah2, Mahnoor Khan1

  • 1Department of Otolaryngology-Head and Neck Surgery, Morsani College of Medicine of the University of South Florida, Tampa, FL, USA.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|May 16, 2025
PubMed

Insights

Platelet-rich products (PRPs) significantly reduced fistula rates in cleft palate repairs. This meta-analysis suggests PRPs are an effective adjunct for improving surgical outcomes in palatoplasty.

Area of Science:

  • Surgical Innovation
  • Regenerative Medicine
  • Craniofacial Surgery

Background:

  • Cleft palate (CP) repair has numerous techniques, yet fistula rates remain high (15-55%).
  • Platelet-rich products (PRPs) are known for accelerating wound healing.
  • Evaluating PRPs' impact on fistula formation post-CP repair is crucial.

Purpose of the Study:

  • To systematically review and meta-analyze the effect of PRPs on fistula rates after primary or secondary cleft palate repair.
  • To assess the efficacy of PRPs as an adjunct in CP surgical management.

Main Methods:

  • A systematic meta-analysis review of randomized controlled trials.
  • Searched multiple databases including MEDLINE, Embase, Pubmed, and Scopus.
  • Included 164 patients undergoing primary or secondary CP repair, comparing PRP vs. no PRP.

Main Results:

  • Five studies with 164 patients were analyzed.
  • Fistula rates were 4.9% in the PRP group and 22.0% in the non-PRP group.
  • PRP use showed a statistically significant reduction in fistula rates (pooled risk ratio: 0.32, p=0.02).

Conclusions:

  • Platelet-rich products (PRPs) significantly reduce fistula rates following cleft palate repair.
  • PRPs may serve as an effective intra-operative adjunct to conventional CP surgery.
  • Further research is needed to explore PRP's impact on other post-operative parameters in CP repair.

Keywords:
cleft palateoronasal fistulapalatoplastyplatelet-rich plasmawound healing

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