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Optic disk findings in hypervitaminosis A.

D F Marcus, P Turgeon, T M Aaberg

    Annals of Ophthalmology
    |July 1, 1985
    PubMed
    Summary
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    Excessive vitamin A intake can cause papilledema, a condition affecting vision. Stopping vitamin A supplements resolves symptoms and optic nerve swelling.

    Area of Science:

    • Ophthalmology
    • Neurology
    • Toxicology

    Background:

    • Papilledema is optic nerve swelling often linked to increased intracranial pressure.
    • Chronic excessive vitamin A intake (hypervitaminosis A) is a potential, yet often overlooked, cause.

    Observation:

    • Presents three cases of papilledema linked to excessive vitamin A consumption.
    • Documents optic disc changes using intravenous fluorescein angiography.
    • Two patients experienced blurred vision and systemic symptoms.

    Findings:

    • Symptoms and papilledema resolved within weeks to months after discontinuing vitamin A.
    • Fluorescein angiographic findings in hypervitaminosis A resemble other papilledema causes.
    • Highlights the potential risks of nonprescription vitamin A supplementation.

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    Implications:

    • Clinicians should consider hypervitaminosis A in papilledema evaluations.
    • Eliciting a history of vitamin A ingestion is crucial for diagnosis.
    • Emphasizes the importance of cautious, informed use of vitamin supplements.