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Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
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Emerging Insights into Corynebacterium Kroppenstedtii Complex Associated Breast Abscesses: A Retrospective Study
Sreethish Sasi1, Manal Mahmoud Mohamed Hamed2, Hamad Elnil Abdelgabar Abdel Hadi1
1Infectious Diseases Division, Department of Medicine, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar.
Infection and Drug Resistance
|May 16, 2025
Summary
The Corynebacterium kroppenstedtii complex (CKC) causes challenging breast abscesses, primarily in pre-menopausal women. Most CKC isolates remain sensitive to vancomycin, linezolid, and rifampicin, though resistance to penicillin and daptomycin is observed.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Women's Health
Background:
- The Corynebacterium kroppenstedtii complex (CKC), encompassing C. kroppenstedtii, C. parakroppenstedtii, and C. pseudokroppenstedtii, is increasingly recognized for its role in breast abscesses and granulomatous mastitis.
- Its lipophilic nature and association with specific patient demographics present diagnostic and therapeutic hurdles.
Purpose of the Study:
- To retrospectively analyze the clinical and microbiological characteristics of CKC isolates from breast tissue.
- To evaluate antibiotic susceptibility patterns of CKC in a clinical setting.
Main Methods:
- Retrospective analysis of 34 CKC isolates from breast tissue collected between October 2016 and March 2024.
- Identification using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS).
- Antibiotic susceptibility testing performed according to Clinical and Laboratory Standards Institute (CLSI) guidelines.
Main Results:
- 31 of 34 isolates were from pre-menopausal women (median age 33), often obese or overweight.
- Breast abscesses were typically unilateral with axillary lymphadenopathy; 58% recurrence within six months was observed.
- High sensitivity to vancomycin, linezolid, and rifampicin; noted resistance to penicillin and daptomycin.
Conclusions:
- CKC is an emerging pathogen in breast infections, necessitating precise diagnostics and tailored treatment.
- Genomic tools are recommended for species differentiation and monitoring antimicrobial resistance.
- Further research is crucial for optimizing management strategies and combating rising antimicrobial resistance.
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