Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

9.6K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
9.6K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.6K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

UbiDash: A UPS proteomic atlas for tissue-aware degrader design.

Cell death and differentiation·2026
Same author

Exploring the protective impacts of <i>Rhodiola rosea</i> extract against vancomycin-induced hepatic and renal toxicity through the activation of Nrf2/HO-1 and MAPK kinases, inhibition of NF-κB and TGF-β1 signaling pathways, role of apoptosis and inflammation associated-markers.

Drug and chemical toxicology·2026
Same author

Dissection versus prosection by anatomical region: Evaluating a regional group dissection curriculum in medical education.

Anatomical sciences education·2026
Same author

Baseline plasma-informed circulating tumor DNA analyses comparing multiplex digital PCR and NGS for longitudinal monitoring in Hodgkin lymphoma.

Blood cancer journal·2026
Same author

Synthesis and characterization of electrochemically polymerized indole on screen-printed Ag-conductive transparency sheet for enzymatic biofuel cell applications.

Scientific reports·2026
Same author

Liposomal nanotherapeutics for cancer treatment: Targeted delivery and immunotherapy.

International journal of immunopathology and pharmacology·2026

Related Experiment Video

Updated: May 17, 2025

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

69.9K

Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer.

Iqra Attique1, Zahra Haider1, Maha Khan2

  • 1Department of Biotechnology, Kinnaird College for Women University, Lahore, Pakistan.

Cancer Medicine
|May 16, 2025
PubMed
Summary

Reactive oxygen species (ROS) play a dual role in cancer, promoting or suppressing tumors based on concentration. Modulating ROS offers promising therapeutic strategies for cancer treatment.

Keywords:
cancerhomeostatic dysregulationreactive oxygen speciessignal transducertumorigenesis

More Related Videos

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

1.9K
Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

37.1K

Related Experiment Videos

Last Updated: May 17, 2025

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

69.9K
Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

1.9K
Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

37.1K

Area of Science:

  • Oncology
  • Biochemistry
  • Cell Biology

Background:

  • Reactive oxygen species (ROS) are implicated in cancer pathogenesis, with cancer cells often exhibiting disrupted redox homeostasis and elevated ROS.
  • ROS influence tumor progression by regulating genes, promoting proliferation, invasion, and angiogenesis at moderate levels.
  • Excessive ROS can induce cellular damage, leading to apoptosis, necroptosis, or ferroptosis.

Purpose of the Study:

  • To review molecular targets in redox homeostasis dysregulation.
  • To examine the impact of ROS on the tumor microenvironment (TME).
  • To assess how ROS modulation contributes to cancer development and therapy.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Analysis of molecular targets and pathways involved in ROS production and signaling.
  • Evaluation of therapeutic strategies targeting ROS in cancer.

Main Results:

  • ROS influence cancer progression via diverse pathways and cellular mechanisms.
  • Targeting ROS synthesis or enhancing ROS accumulation shows potential anticancer effects.
  • Therapeutic strategies modulating ROS can impair tumor growth and interact with the TME.

Conclusions:

  • ROS act as both cancer promoters and suppressors, depending on intracellular concentration.
  • The complex role of ROS presents opportunities for targeted cancer therapies.
  • Modulating ROS holds promise as a synergistic approach alongside conventional cancer treatments.