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Ouhanamide, an Antiparasitic Linear Lipopeptide from a Marine Okeania sp. Cyanobacterium
Mizuho Niiyama1, Naoaki Kurisawa1, Kairi Umeda1
1Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Abstract:
Ouhanamide (1), a new linear lipopeptide consisting of a long-chain fatty acid with a β-branched methyl group, was isolated from a marine Okeania sp. cyanobacterium. The overall structure was elucidated by a combination of various spectroscopic analyses, degradation reactions, and derivatizations. Ouhanamide (1) showed selective antiparasitic activity (IC50 = 1.2 ± 0.1 μM against Trypanosoma brucei rhodesiense and IC50 = 4.2 ± 0.9 μM against Plasmodium falciparum) without cytotoxicity at 10 μM against HeLa cells.
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