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Updated: Jul 15, 2026
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Mycobacterium tuberculosis shikimate kinase inhibitory activity of a glycodidepside mixture from Cosmospora sp.
Eka Siska1,2, Novriyandi Hanif2, Gustini Syahbirin2
1Research Center for Vaccine and Drug, Research Organization for Health, National Agency of Research and Innovation (BRIN), West Java, Indonesia.
Abstract:
Screening of Indonesian microbial extracts identified Cosmospora sp. BioMCC-f.T-7332 as a source of Mycobacterium tuberculosis shikimate kinase (MtSK) inhibitors. A mixture of alkylated glycodidepsides TPI-1 and TPI-2 was obtained as the inhibitor (IC50 = 1.5 µg/mL) with low cytotoxicity. Although improvements in cell permeability are necessary, didepsides may serve as starting points for the development of antitubercular agents targeting MtSK.
