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Updated: Jul 13, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism

Maria M Shchepinova1, Rachel Richardson2, Jack W Houghton1

  • 1Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, 82 Wood Lane, London W12 0BZ, UK.

Cell Chemical Biology
|May 16, 2025
PubMed

Keywords:
APEX2G protein-coupled receptorGPCRLHRendocytosisendosomeinteractomeisobaric taggingluteinizing hormone receptormass spectrometryproximity labelingproximity proteomicssignalingvery early endosome

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