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Published on: May 19, 2014
Cell cycle regulation by the ribotoxic stress response
Connor D McKenney1, Sergi Regot2
1The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University, Baltimore, MD, USA; Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Trends in Cell Biology
|May 16, 2025
Summary
Ribosomes and the ribotoxic stress response (RSR) regulate stress-activated protein kinases (SAPKs), influencing cell fate and proliferation. This review details how RSR-SAPK signaling impacts cell cycle transitions, affecting senescence and cancer.
Area of Science:
- Cellular Biology
- Molecular Biology
- Biochemistry
Background:
- Cells require mechanisms to sense and respond to environmental stimuli for survival.
- Stress-activated protein kinases (SAPKs) form a crucial signaling network regulating cellular behavior.
- Recent research highlights the role of ribosomes and the ribotoxic stress response (RSR) in modulating SAPK signaling.
Purpose of the Study:
- To review the emerging role of the RSR in regulating the SAPK network.
- To explore the impact of RSR-SAPK signaling on cell fate determination, including proliferation, senescence, and cancer.
- To specifically examine the influence of ribotoxic stress on cell cycle regulation by the p38 SAPK.
Main Methods:
- Literature review of recent studies on SAPKs, RSR, and cell cycle regulation.
- Analysis of signaling pathways integrating RSR and SAPK networks.
- Focus on the p38 SAPK pathway and its interaction with ribotoxic stress.
Main Results:
- Ribosomes and RSR are critical regulators of SAPK signaling.
- RSR-SAPK signaling significantly impacts cellular proliferation.
- Ribotoxic stress affects key cell cycle transitions, with implications for cancer and senescence.
Conclusions:
- The RSR-SAPK pathway is a key determinant of cell fate.
- Understanding RSR-mediated regulation of p38 signaling is crucial for cancer and senescence research.
- Further investigation into RSR-SAPK interactions can reveal novel therapeutic targets.
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