Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulated mRNA Transport02:22

Regulated mRNA Transport

6.2K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In-hospital detection of deep vein thrombosis after surgical treatment of open patellar fractures.

Scientific reports·2026
Same author

Artificial Intelligence for Assessment and Feedback in Medical Education: Bibliometric Mapping Study and Thematic Evidence Map.

JMIR medical education·2026
Same author

Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging.

Nature communications·2026
Same author

Iso-Height Axis Provides More Physiologic Description of Condylar Kinematics and Frontal Plane Stability During Functional Activities After Unicompartmental Knee Arthroplasty.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same author

Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche.

Bone research·2026
Same author

In-hospital deep vein thrombosis after tibial plateau fractures: incidence, laterality/anatomy, and risk factors in a multicenter retrospective cohort of 3366 patients.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology·2026

Related Experiment Video

Updated: May 20, 2025

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.4K

Advances in spatial transcriptomics and its application in the musculoskeletal system.

Haoyu Wang1,2,3, Peng Cheng4, Juan Wang1,2,3

  • 1Department of Orthopedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.

Bone Research
|May 16, 2025
PubMed
Summary

Spatial transcriptomics reveals gene expression and cell location in the musculoskeletal system. This review summarizes its advances, applications in development and disease, and future directions for musculoskeletal research.

More Related Videos

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.8K
A Novel Application of Musculoskeletal Ultrasound Imaging
10:53

A Novel Application of Musculoskeletal Ultrasound Imaging

Published on: September 17, 2013

23.3K

Related Experiment Videos

Last Updated: May 20, 2025

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.4K
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.8K
A Novel Application of Musculoskeletal Ultrasound Imaging
10:53

A Novel Application of Musculoskeletal Ultrasound Imaging

Published on: September 17, 2013

23.3K

Area of Science:

  • Biomedical research
  • Genomics
  • Tissue engineering

Background:

  • Bulk and single-cell RNA sequencing offer insights into musculoskeletal system heterogeneity.
  • Understanding spatial cell localization and interactions remains crucial for tissue context.
  • Spatial transcriptomics emerges as a key technology for in situ tissue analysis.

Purpose of the Study:

  • To review recent advances in spatial transcriptomics.
  • To highlight its applications in musculoskeletal research.
  • To discuss future directions and challenges in the field.

Main Methods:

  • Overview of spatial transcriptomics data acquisition techniques.
  • Emphasis on representative and novel technologies.
  • Outline of a workflow for applying spatial transcriptomics to musculoskeletal research.

Main Results:

  • Spatial transcriptomics aids in understanding musculoskeletal development and physiological mechanisms.
  • It has been applied to study inflammatory, traumatic, degenerative, and tumorous musculoskeletal diseases.
  • The technology reveals spatial gene expression and cellular interactions within tissues.

Conclusions:

  • Spatial transcriptomics is revolutionizing musculoskeletal research by providing spatial context to gene expression.
  • It offers new avenues for investigating disease mechanisms and developing targeted therapies.
  • Continued technological advancements will further expand its utility in the musculoskeletal field.