Green-Reduced Biodegradable Core-Shell Smart-Responsive MOFs for Photothermal-Enhanced Chemo-Chemodynamic in Tumor...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Oncology

Background:

• Metal-organic frameworks (MOFs) offer high porosity and tunable properties for drug delivery.
• Developing targeted and stimuli-responsive systems is crucial for effective cancer therapy.
• Existing treatments face challenges like poor targeting and side effects.

Purpose of the Study:

• To design and synthesize a core-shell nanocomposite (PAZDH) for enhanced cancer treatment.
• To investigate the synergistic effects of chemodynamic therapy, chemotherapy, and photothermal therapy.
• To evaluate the targeted delivery and tumor ablation efficacy of the PAZDH nanocomposite.

Main Methods:

• Fabrication of a core-shell nanocomposite (HA@DOX-PDA@Bio-Ag/ZIF-8) using polydopamine-coated silver nanoparticles and ZIF-8.
• Utilizing CD44 receptor targeting for active tumor aggregation.
• Employing pH-sensitive degradation for controlled release of Bio-Ag NPs and doxorubicin (DOX).
• Investigating near-infrared light (NIR) triggered chemodynamic reactions and photothermal therapy (PTT).

Main Results:

• The PAZDH nanocomposite demonstrated active aggregation at tumor sites.
• Smart-responsive release of Bio-Ag NPs and DOX was achieved.
• Bio-Ag NPs induced apoptosis by generating cytotoxic hydroxyl radicals (·OH).
• Photothermal therapy enhanced drug release and ·OH generation, leading to synergistic chemo-chemodynamic therapy.
• Efficient tumor ablation with up to 91.72% inhibition of solid tumors was observed.

Conclusions:

• The developed PAZDH nanocomposite shows significant potential for tumor treatment.
• This strategy offers a promising approach for smart-responsive MOF-based cancer therapy.
• The combination of therapies provides a potent platform for overcoming tumor complexities.