Double-Responsive Metallic Magnetic Nanoparticles Based on Tumor Microenvironment "Leverage" Rebalancing for Triple...

Area of Science:

• Biomedical Engineering
• Nanomedicine
• Oncology

Background:

• Targeting tumor redox balance, specifically reactive oxygen species (ROS) and glutathione (GSH), is a key cancer therapy strategy.
• Conventional single-agent therapies have limited efficacy due to insufficient oxidative stress amplification in tumor cells.

Purpose of the Study:

• To design and evaluate novel pH- and GSH-responsive nanoparticles for synergistic multimodal cancer therapy.
• To investigate the combined chemodynamic therapy (CDT), photothermal therapy (PTT), and chemotherapy (CT) effects of the developed nanomaterial.

Main Methods:

• Fabrication of pH- and GSH-double-responsive metallic magnetic Ag-NH2-CoFe2O4@C@DOX nanoparticles (ANFCD NPs).
• Evaluation of ANFCD NPs as Fenton catalysts and GSH depletors in the tumor microenvironment (TME).
• Assessment of photothermal conversion efficiency and magnetically targeted tumor accumulation.
• Investigation of DOX release and synergistic therapeutic effects.

Main Results:

• ANFCD NPs effectively disrupted TME redox balance, potentiating CDT via Fenton catalysis and GSH depletion.
• High photothermal conversion efficiency and magnetic targeting enhanced PTT.
• Responsive DOX release achieved chemotherapy, with hyperthermia further boosting CDT and drug release.
• Synergistic multimodal therapy demonstrated significant tumor cell eradication.

Conclusions:

• ANFCD NPs represent a promising therapeutic agent for disrupting redox homeostasis in cancer.
• The developed nanomaterial effectively integrates CDT, PTT, and CT for augmented multimodal collaborative therapy.
• This approach holds potential for future applications in nanomedical science for cancer treatment.