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Synergistic effect and biochemical evaluation of kolaviron and quercetin on rat-model benign prostate hyperplasia
Ujong P Ujong1,2, Mbang E Ibor2, Iwara A Iwara2
1Department of Medical Biochemistry, Faculty of Basic Medical Sciences, University of Cross River State, Okuku Campus, Cross River State, 540001, Nigeria.
Abstract:
This study examined the effects of kolaviron and quercetin, individually and combined, on biochemical and histopathological changes in testosterone-induced benign prostatic hyperplasia (BPH) in male Wistar rats. Forty-two rats were divided into six groups, with BPH induced in all but the control group. Treatments included kolaviron, quercetin, their combination, and finasteride. BPH increased PSA, 5-α reductase, DHT, kidney and liver function markers, and altered lipid profiles. Treatments reduced these elevations and improved testosterone and HDL-c levels. Findings suggest that kolaviron and quercetin effectively ameliorate BPH, indicating their potential as affordable, non-invasive options for BPH management.
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