Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lung Capacity01:47

Lung Capacity

48.5K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
48.5K
Pulmonary Function Tests01:25

Pulmonary Function Tests

280
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
280
Longitudinal Research02:20

Longitudinal Research

11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
Longitudinal Studies01:26

Longitudinal Studies

101
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
101
Physical Assessment of the Respiratory Tract I: Health History01:28

Physical Assessment of the Respiratory Tract I: Health History

139
Physical assessment of the respiratory tract is critical to patient care. It allows healthcare professionals to identify and manage various respiratory conditions. The process involves a combination of subjective and objective data collection.
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and...
139
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

215
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
215

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomarkers of Pre-COPD Lung Function Trajectories in Middle Age: A Prospective Study From 1st to 6th Decade.

Respirology (Carlton, Vic.)·2026
Same author

Moving to better COPD care-changes to and challenges for GOLD.

American journal of respiratory and critical care medicine·2026
Same author

The Potential Role of DPP-1 Inhibitors in Chronic Obstructive Pulmonary Disease.

Archivos de bronconeumologia·2026
Same author

Clinical impact of mucus plugs in bronchiectasis.

Scientific reports·2026
Same author

How artificial intelligence could improve the diagnosis and management of COPD: a perspective from GOLD.

American journal of respiratory and critical care medicine·2026
Same author

A Brief History of COPD: As Told by Some of Its Senior Scientists and Clinicians.

Journal of clinical medicine·2026

Related Experiment Video

Updated: May 20, 2025

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

4.2K

General population-based lung function trajectories over the life course: an accelerated cohort study.

Judith Garcia-Aymerich1, Martí de Las Heras1, Anne-Elie Carsin1

  • 1ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain.

The Lancet. Respiratory Medicine
|May 18, 2025
PubMed
Summary

This study reveals lung function (FEV1 and FVC) increases in two phases during childhood and adolescence, peaking in early adulthood. Lung function declines earlier than previously thought, with FEV1/FVC ratio decreasing throughout life.

More Related Videos

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

10.5K
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.4K

Related Experiment Videos

Last Updated: May 20, 2025

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

4.2K
Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

10.5K
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.4K

Area of Science:

  • Pulmonology
  • Epidemiology
  • Life Course Research

Background:

  • Current understanding of lung function growth and decline is limited by fragmented and potentially biased data.
  • Establishing general population-based life course trajectories is crucial for accurate health assessments.
  • Identifying breakpoints and plateaus in lung function is essential for understanding respiratory health dynamics.

Purpose of the Study:

  • To empirically derive general population-based life course trajectories for lung function.
  • To identify critical breakpoints and plateaus in lung function across the lifespan.
  • To investigate the influence of asthma and smoking on lung function trajectories.

Main Methods:

  • Pooled data from eight European and Australian general population cohort studies to create an accelerated cohort.
  • Utilized cross-classified three-level linear mixed models to derive sex-specific lung function trajectories (FEV1, FVC, FEV1/FVC ratio) from ages 4-80.
  • Employed Bayesian time-series decomposition to identify breakpoints and plateaus, with stratified analyses for asthma and smoking status.

Main Results:

  • FEV1 and FVC trajectories showed two distinct phases of increase, peaking in early adulthood (around age 20-23) before declining.
  • Lung function decline commenced earlier than previously reported, with no plateau observed after the peak.
  • FEV1/FVC ratio demonstrated a continuous decrease throughout life. Persistent asthma and smoking were associated with adverse lung function outcomes.

Conclusions:

  • Lung function (FEV1, FVC) follows a biphasic growth pattern, peaking in early adulthood and declining thereafter, with earlier onset of decline than previously understood.
  • The FEV1/FVC ratio consistently decreases across the life course.
  • These findings establish a vital framework for assessing and monitoring respiratory health throughout life, highlighting the impact of asthma and smoking.