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Related Concept Videos

Blinding01:11

Blinding

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Bleaching efficacy and tooth sensitivity using violet LED - single-blind randomized controlled trial.

Gabriela Torres Zanin1,2, Edgar Pedreiro Ribeiro1,2, Bianca Medeiros Maran3,4

  • 1Anhanguera-Uniderp University, Campo Grande, Brazil.

Lasers in Medical Science
|May 18, 2025
PubMed
Summary
This summary is machine-generated.

Violet LED (VLED) combined with 35% hydrogen peroxide (HP) or HP alone showed superior tooth whitening but increased tooth sensitivity compared to VLED alone. VLED alone was less effective for bleaching.

Keywords:
Dentin sensitivityRandomized clinical trialsTooth bleaching

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Area of Science:

  • Dental Materials Science
  • Photochemistry in Dentistry
  • Aesthetic Dentistry

Background:

  • Tooth discoloration is a common aesthetic concern.
  • Hydrogen peroxide (HP) and light-activation are widely used for dental bleaching.
  • Violet LED (VLED) offers a novel approach to light-activated bleaching.

Purpose of the Study:

  • To evaluate the bleaching efficacy and tooth sensitivity (TS) of violet LED (VLED) with and without 35% hydrogen peroxide (HP).
  • To compare the outcomes of HP only, VLED only, and HP + VLED treatments.

Main Methods:

  • A single-blind randomized controlled trial involving 84 participants.
  • Three treatment groups: 35% HP, VLED, and HP + VLED, with three sessions at 7-day intervals.
  • Colorimetric measurements (ΔEab, ΔE00, ΔSGU, ΔWID) and visual analogue scale (VAS) for tooth sensitivity were used.

Main Results:

  • HP and HP + VLED groups demonstrated significantly higher bleaching efficacy compared to VLED alone.
  • The HP + VLED and HP groups reported significantly higher risk and intensity of tooth sensitivity.
  • Bleaching efficacy of VLED alone was lower than HP and HP + VLED at 7 and 30 days post-treatment.

Conclusions:

  • 35% HP, with or without VLED, provides superior tooth whitening but is associated with increased tooth sensitivity.
  • VLED alone shows lower bleaching efficacy and is associated with less tooth sensitivity.
  • Combining 35% HP with VLED does not enhance bleaching efficacy over HP alone but increases tooth sensitivity.